Detection of Microglial Activation in an Acute Model of Neuroinflammation Using PET and Radiotracers¹¹C-(<i>R</i>)-PK11195 and¹⁸F-GE-180

Abstract

(18)F-GE-180 is able to reveal sites of activated microglia in both gray and white matter. However, the signal is increased by the presence of activated astrocytes. Therefore, (18)F-GE-180 is a promising new fluorinated longer-half-life tracer that reveals the presence of activated microglia in a manner that is superior to (11)C-(R)-PK11195 due to the higher binding potential observed for this ligand.