A novel inhibitor of Smad‐dependent transcriptional activation suppresses tissue fibrosis in mouse models of systemic sclerosis - Concepedia

Concepedia

Publication | Closed Access

A novel inhibitor of Smad‐dependent transcriptional activation suppresses tissue fibrosis in mouse models of systemic sclerosis

51

Citations

31

References

2009

Year

Minoru Hasegawa, Yukiyo Matsushita, Mayuka Horikawa, Kiyoshi Higashi, Yoshitaka Tomigahara, Hideo Kaneko, Fumiaki Shirasaki, Manabu Fujimoto, Kazuhiko Takehara, Shinichi Sato

Arthritis & Rheumatism

Abstract

These results demonstrate that HSc025 is a novel inhibitor of TGFbeta/Smad signaling, resulting in the improvement of skin and pulmonary fibrosis. Orally available HSc025 might therefore be useful in the treatment of SSc.

References

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