British Journal of Haematology · 2006 · 21 citations · 10 references
MedicineHematologyOncologyHematologic OncologyImmunopathologyMolecular OncologyBcl-2 Family ProteinsImmuno-oncology BiomarkersLymphoid NeoplasmsLymphoid Tissue PathologyLymphoid TumorsTumor AntigensImmunohistochemical BiomarkersImmunohistochemical DetectionImmunohistochemical MarkersImmunohistochemical StainingLymphoma BiomarkersLymphoma GradingLymphoma HistopathologyMcl-1 Function
In the present study, we investigated the expression of Mcl-1 and Bcl-2 by immunohistochemistry in 85 patients of grades 1-3 and transformed follicular lymphoma (FL). In lymphoma tissue, centroblasts uniformly expressed high levels of Mcl-1 (Mcl-1(hi)) whereas centrocytes demonstrated low Mcl-1 expression (Mcl-1(lo)). Bcl-2 expression in centroblasts/centrocytes was reciprocal to Mcl-1 staining in most cases. A high number of Mcl-1(hi) centroblasts in tissue sections (> or =200/high-power field) correlated with poor overall survival (P < 0.001), independent of the International Prognostic Index and FL grade. This suggests that the number of centroblasts with strong Mcl-1 staining is associated with clinical outcome in FL patients.
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