Increase in anaphylaxis-related hospitalizations but no increase in fatalities: An analysis of United Kingdom national anaphylaxis data, 1992-2012

TLDR

Anaphylaxis incidence appears to be rising, yet data on fatal outcomes are scarce and may be influenced by heightened awareness and changing patient and provider behaviors. The study aimed to chart trends in anaphylaxis admissions and fatalities across age, sex, and trigger in England and Wales over 1992‑2012. Researchers extracted hospital admission and fatality records from national databases, cross‑checked deaths against a prospective registry, and analyzed time trends and age distributions for food, drug, and insect‑sting–induced anaphylaxis. Hospital admissions for anaphylaxis surged 615 % over the two decades while annual fatality rates remained steady at 0.047 per 100 000; drug‑ and insect‑sting–related cases peaked in those over 60, whereas food‑triggered admissions and deaths were most common among young adults, indicating age‑specific vulnerability without an overall rise in fatality incidence.

Abstract

The incidence of anaphylaxis might be increasing. Data for fatal anaphylaxis are limited because of the rarity of this outcome.We sought to document trends in anaphylaxis admissions and fatalities by age, sex, and cause in England and Wales over a 20-year period.We extracted data from national databases that record hospital admissions and fatalities caused by anaphylaxis in England and Wales (1992-2012) and crosschecked fatalities against a prospective fatal anaphylaxis registry. We examined time trends and age distribution for fatal anaphylaxis caused by food, drugs, and insect stings.Hospital admissions from all-cause anaphylaxis increased by 615% over the time period studied, but annual fatality rates remained stable at 0.047 cases (95% CI, 0.042-0.052 cases) per 100,000 population. Admission and fatality rates for drug- and insect sting-induced anaphylaxis were highest in the group aged 60 years and older. In contrast, admissions because of food-triggered anaphylaxis were most common in young people, with a marked peak in the incidence of fatal food reactions during the second and third decades of life. These findings are not explained by age-related differences in rates of hospitalization.Hospitalizations for anaphylaxis increased between 1992 and 2012, but the incidence of fatal anaphylaxis did not. This might be due to increasing awareness of the diagnosis, shifting patterns of behavior in patients and health care providers, or both. The age distribution of fatal anaphylaxis varies significantly according to the nature of the eliciting agent, which suggests a specific vulnerability to severe outcomes from food-induced allergic reactions in the second and third decades.