In vivo measurement of brain tumor pH using [¹¹C]DMO and positron emission tomography

Abstract

Abstract In vivo measurements of regional brain tissue/tumor pH ( r pH) have been accomplished in 9 patients with primary or metastatic brain tumors using[ 11 C]dimethyloxazolidinedione ([ 11 C]DMO) and positron emission tomography. Tumor r pH values ranged from 6.88 to 7.26, whereas gray matter and white matter r pH values ranged from 6.74 to 7.09 and from 6.77 to 7.03, respectively. Our result, which are consistent with reported [ 14 C]DMO autoradiographic measurements of brain and tumor pH, suggest that the pH microenvironment of brain tumors is not more “acidic” than that of normal gray or white matter.