Concepedia

Bioactive Cytochalasins from <i>Aspergillus flavipes</i>, an Endophytic Fungus Associated with the Mangrove Plant <i>Acanthus ilicifolius</i>

Zhenjian Lin, Guo‐Jian Zhang, Tianjiao Zhu, Rui Liu, Hongjuan Wei, Qianqun Gu

Helvetica Chimica Acta · 2009 · 69 citations · 8 references

DOI

Concepts

Abstract

Abstract Five new cytochalasins, Z 16 –Z 20 ( 1 – 5 ), and three known ones, 6 – 8 , were isolated from Aspergillus flavipes , an endophytic fungus associated with Acanthus ilicifolius. Their structures were elucidated on the basis of comprehensive spectral analysis. Cytochalasin Z 17 ( 2 ) and rosellichalasin ( 8 ) showed cytotoxic activities against A‐549 cell lines with IC 50 values of 5.6 and 7.9 μ M , respectively.

References

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Novel Open-Chain Cytochalsins from the Marine-Derived Fungus <i>Spicaria elegans</i>

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10-Phenyl-[12]-cytochalasins Z<sub>7</sub>, Z<sub>8</sub>, and Z<sub>9</sub> from the Marine-Derived Fungus <i>Spicaria </i><i>e</i><i>legans</i>

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The effects of cytochalasins on lymphocytes. Identification of distinct cytochalasin-binding sites in relation to mitogenic response and hexose transport.

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