Hypertrophic Obstructive Cardiomyopathy in an Infant — Propranolol Therapy for Three Years

Abstract

ALTHOUGH the beta-adrenergic blocking drug, propranolol, has been used in adults with hypertrophic obstructive cardiomyopathy,1 2 3 its use in children has not yet been reported. The youngest child in whom the diagnosis has been confirmed was one year of age,4 and operative correction was unsuccessful. The eight-week-old child described below had a three-year follow-up of propranolol treatment. Because there was no information on pediatric dosage, therapy was monitored by measurements of plasma levels of the drug.Case ReportThis infant with no relevant past or family history was delivered normally at full-term weighing 3.7 kg. She failed to thrive and weighed . . .