Concepedia

Involvement of the Basal Cholinergic Forebrain in the Mediation of General (Propofol) Anesthesia

F.-Z. Laalou, Anne Pereira de Vasconcelos, Philippe Oberling, Hélène Jeltsch‐David, Jean‐Christophe Cassel, Laure Pain

Anesthesiology · 2008 · 62 citations · 30 references

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Abstract

The anesthetic potency of propofol was increased in all rats with hippocampal lesions, whatever the injection sites, compared with controls. These results demonstrate that a cholinergic dysfunction in the basal forebrain potentiates the anesthetic effects of propofol.

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