Prevention of Microsurgical Anastomotic Thrombosis Using Aspirin, Heparin, and the Glycoprotein IIb/IIIa Inhibitor Tirofiban

Abstract

Combination therapy with aspirin, heparin, and tirofiban significantly increases arterial and venous patency and decreases anastomotic thrombus formation in thrombogenic anastomoses in rats. The role of glycoprotein IIb/IIIa inhibitors in microsurgery warrants further investigation.