EFFECTS OF THE PANCREAS AND THE ADRENALS UPON PRODUCTION OF NITROGEN STORAGE WITH PITUITARY PREPARATIONS

Abstract

NUMEROUS STUDIES indicate that the effect of anterior pituitary preparations upon metabolism of protein and carbohydrate is greatly influenced by the pancreas. In experiments conducted in this laboratory upon normal fed bitches, single large injections of a growth preparation induced storage of nitrogen, sudden gains in weight, little or no glycosuria or hyperglycemia, and a negligible rise in blood fat. In depancreatizied bitches receiving constant diets and uniform daily doses of insulin the effects of the same preparation were practically reversed. Losses of weight and nitrogen occurred, as well as greatly increased glycosuria, hypergly cemia, lipemia, and ketonuria (1). If the response of normal animals depends upon ability to increase or mobilize their insulin supply, one should be able to produce the same response in depancreatised animals by raising the insulin dosage when the growth preparation is injected. Such experiments form the first part of the present study.