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Enhydrazine, XXV Einige Derivate des 1-Dimethylamino-2(1H)-chinolinons/Enehydrazines, XXV Some Derivatives of 1-Dimethylamino-2(1 H)-quinolinone
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1979
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Abstract ReactionOrganic ChemistryChemistryHeterocycle ChemistryChemical DerivativePharmaceutical Chemistry-Quinolinones 12Stereoselective SynthesisBiochemistryPharmacologyEnantioselective SynthesisHeterocyclicNatural SciencesDrug DiscoveryMedicineXxv Einige DerivateDerivative (Chemistry)Synthetic ChemistryAromatic 1-Dimethylamino- 2Drug Analysis
Abstract Reaction of the N,N-dimethyl enehydrazines 1 a-c with acetylene carboxylates gives the 1-dimethylamino-7,8-dihydro-2,5(1H,6H)-quinolinediones 5a and 6a-c together with some by-products of the enehydrazine (2a, 3a, 4a) and 4,5,6,7-tetrahydro-1H-indol-4-one type (7a-c). Compounds 6b and 6c have been degraded to the fully aromatic 1-dimethylamino- 2(1H)-quinolinones 12 b and 12 c.