Evaluation of the Lactulose/Mannitol and ⁵¹ Cr-Ethylenediaminetetraacetic Acid/ ¹⁴ C-Mannitol Methods for Intestinal Permeability: Influence of Urinary Volume, Sex, Age, Smoking, and Intestinal Disease on Marker Excretion

Abstract

Correction for urinary volume substantially reduces variability in small-pore marker excretion. Excretion of both types of markers tends to decrease with age, the large-pore/small-pore marker ratio remaining unchanged. Smoking does not affect small-intestinal permeability. 14C-mannitol is preferred to chemically determined mannitol owing to lower test variability.