A STUDY ON THE METABOLISM OF LIPOIC ACID AND LIPOAMIDE

Abstract

1. Lipoic acid or lipoamide administered orally to animals seemed to be easily absorbed from the digestive tract and to be eliminated in the urine largely as the oxidation products of these substances.2. Lipoamide was easily converted to lipoic acid both in the in vitro and in vivo experiments.3. Urinary excretion of S35-compounds, after administering S35-lipoic acid or S35-lipoamide, was found to be increased in the rats poisoned with CCl4 or those with alloxan diabetes as compared with normal rats.