Publication | Closed Access
Efficient Construction of Polycyclic Derivatives via a Highly Selective Cu<sup>I</sup>-Catalyzed Domino Reductive-Aldol Cyclization
82
Citations
46
References
2009
Year
Six-membered RingsAsymmetric CatalysisNovel OrganocatalystsDerivativesEngineeringHeterocyclic/Diphosphane LigandOrganic ChemistryOrganometallic CatalysisCatalysisStereoselective SynthesisChemistryEfficient ConstructionVersatile MethodologyEnantioselective SynthesisBiomolecular EngineeringPolycyclic Derivatives
A versatile methodology for the diastereo- and enantioselective domino reductive-aldol cyclizations is reported. By using a copper (I)/diphosphane ligand, various five- and six-membered rings were generated with good to excellent diastereo- and enantioselectivities (cis:trans up to 100:0 and ee up to 95%).
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