<i>In Vitro</i> and <i>In Vivo</i> Evaluation of Adenovirus Combined Silk Fibroin Scaffolds for Bone Morphogenetic Protein-7 Gene Delivery

Abstract

Silk scaffolds carrying BMP-7 encoding adenoviruses can effectively transfect cells and enhance both in vitro and in vivo osteogenesis. The findings of this study indicate that silk fibroin is a promising biomaterial for gene delivery to repair critical-sized bone defects.