Enantioselective Catalytic Borane Reductions of Achiral Ketones: Synthesis and Application Of New Catalysts Prepared from<i>(S)-Tert</i>-Leucine and (<i>S</i>)-Azetidinecarboxylic Acid

Abstract

Abstract Enantiocontrolled reduction of prochiral ketones with borane in the presence of homochiral amino alcohols 1—3 as enantioselective catalysts afforded the corresponding secondary alcohols in moderate to high (69 to >99 %) optical yields.