Urinary 8-hydroxydeoxyguanosine and its analogs as DNA marker of oxidative stress: development of an ELISA and measurement in both bladder and prostate cancers

Production of large amounts of hydrogen peroxide by human tumor cells.

Ted P. Szatrowski, Carl Nathan · PubMed · 1991 · 2.5K citations

Life Sciences, Biochemistry, Oncology +17

Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage

Arne Klungland, Ian Rosewell, Stephan Hollenbach et al. · Proceedings of the National Academy of Sciences · 1999 · 798 citations

Life Sciences, Genetics, Molecular Biology +17

Role of oxidative DNA damage in cancer initiation and promotion.

Henrik E. Poulsen, Helene Priemé, Steffen Loft · PubMed · 1998 · 346 citations

Medicine, Molecular Biology, Oncology +17

Biomarker evidence of DNA oxidation in lung cancer patients: association of urinary 8‐hydroxy‐2′‐deoxyguanosine excretion with radiotherapy, chemotherapy, and response to treatment

Marina Erhola, Shinya Toyokuni, K. Okada et al. · FEBS Letters · 1997 · 265 citations · Full text

Medicine, Cancer Biology, Oncology +13

Quantification of 8-oxo-guanine and guanine as the nucleobase, nucleoside and deoxynucleoside forms in human urine by high-performance liquid chromatography-electrospray tandem mass spectrometry

Allan Weimann · Nucleic Acids Research · 2002 · 253 citations · Full text

Pharmacy, Biochemistry, Molecular Biology +15