The Persistence of the Alcohol‐Disulfiram Reaction After Discontinuation of Drug in Patients With and Without Liver Disease

Abstract

Fifty‐two normals and 15 patients with liver disease were studied with a 5‐g challenge dose of ethanol at various intervals after stopping disulfiram 24 hr previously. The reaction to disulfiram and ethanol does not persist beyond 24 hr in normal patients, but in patients with abnormal liver function, it may continue for as long as 96 hr.