IL-1β signaling is required for mechanical allodynia induced by nerve injury and for the ensuing reduction in spinal cord neuronal GRK2

An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat

Sun Ho Kim, Jin Mo Chung · Pain · 1992 · 3K citations

Pain Disorders, Peripheral Nerve Injury, Pain Medicine +27

Inhibition of Microglial Activation Attenuates the Development but Not Existing Hypersensitivity in a Rat Model of Neuropathy

Raghavendra Vasudeva, Flobert Tanga, Joyce A. DeLeo · Journal of Pharmacology and Experimental Therapeutics · 2003 · 787 citations

ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model

Zhi‐Ye Zhuang, Peter Gerner, Clifford J. Woolf et al. · Pain · 2005 · 766 citations

Pain Medicine, Erk Kinase, Neuropathic Pain +18

Activation of p38 mitogen‐activated protein kinase in spinal hyperactive microglia contributes to pain hypersensitivity following peripheral nerve injury

Makoto Tsuda, Akito Mizokoshi, Yukari Shigemoto‐Mogami et al. · Glia · 2003 · 525 citations

Pain Disorders, Tactile Allodynia, Peripheral Nerve Injury +23

Tumor Necrosis Factor-α Induces Mechanical Allodynia after Spinal Nerve Ligation by Activation of p38 MAPK in Primary Sensory Neurons

Maria Schäfers, Camilla I. Svensson, Claudia Sommer et al. · Journal of Neuroscience · 2003 · 520 citations · Full text

Pain Disorders, Peripheral Nerve Injury, Pain Medicine +24