Bispectral index, predicted and measured drug levels of target‐controlled infusions of remifentanil and propofol during laparoscopic cholecystectomy and emergence

Abstract

Present systems for TCI of remifentanil and propofol result in large intra- and interindividual variations in measured drug levels, and measured levels differ from target. There may be possible interaction between the two anaesthetics at a pharmacokinetic level. Within the level of anaesthesia studied here, BIS was not an indicator of the actual drug levels. Women woke up significantly faster than men.