Reverse Selection for Differential Response to the Locomotor Stimulant Effects of Ethanol Provides Evidence for Pleiotropic Genetic Influence on Locomotor Response to Other Drugs of Abuse

Abstract

Genes that influence the locomotor response to ethanol also influence locomotor response to other drugs with stimulant effects in the FAST and SLOW mice. The current data most strongly support this conclusion for sensitivity to morphine and nicotine.