Combined inhibition of neutral endopeptidase and angiotensin-converting enzyme by sampatrilat in essential hypertension*

Abstract

The increasing efficacy of sampatrilat compared with lisinopril over 10 days could not be attributed to an increase in plasma ACE inhibition, suggesting that the NEP inhibitor activity of sampatrilat may have contributed to its antihypertensive action. NEP inhibition may enhance the antihypertensive effect of ACE inhibition.