Secondary metabolites by chemical screening. Part 19. SM 196 A and B, novel biologically active angucyclinones from Streptomyces sp.

Abstract

Application of a method of chemical screening2*, which based on the prior work of Zahner et al.3\ gave rise to the detection, isolation and structure elucidation of two new angucyclinones4) exhibiting biological activity. In addition, the known compounds 6-deoxy-8-0-methylrabelomycin (3)5' 6) and X-14881 E (4)7) were detected in the same culture broth.