Up-Regulation in Receptor for Advanced Glycation End-Products in Inflammatory Circumstances in Bovine Coccygeal Intervertebral Disc Specimens In Vitro

Abstract

This is the first report to show the correlation between IL-1beta and AGEs-RAGE complex in IVD. Our results suggested that the increased RAGE expression in inflammatory circumstances and interaction with AGEs are risk factors in decreasing of aggrecan content in nucleus pulposus.