Down-Regulated MicroRNA-152 Induces Aberrant DNA Methylation in Hepatitis B Virus–Related Hepatocellular Carcinoma by Targeting DNA Methyltransferase 1

Abstract

Our findings suggest that miR-152 is frequently down-regulated and regulates DNMT1 in HBV-related HCC. These findings support a tumor-suppressive role of miR-152 in the epigenetic aberration of HBV-related HCC and the potential development of miRNA-based targeted approaches for the treatment of HBV-related HCC.