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Coumestans as the Main Active Principles of the Liver Drugs<i>Eclipta alba</i>and<i>Wedelia calendulacea</i><sup>1</sup>
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1986
Year
BotanyEclipta AlbaSecondary MetabolitePolyphenolicsOxidative StressMedicinal ChemistryDrug Eclipta AlbaPhytopharmacologyPhytochemicalCoumestans WedelolactoneBiochemistryActive IngredientLiver PhysiologyMetabolomicsPharmacologyMain Active PrinciplesNatural SciencesHerbal MedicineHerb-drug InteractionPhytochemistryMedicineDrug Discovery
From the ethyl acetate-soluble fraction of the drug Eclipta alba (L.) Hassk. Asteraceae, besides a flavonoid and simple phenolcarboxylic acids, the coumestans wedelolactone and demethyl-wedelolactone were isolated as the main active principles. Both constituents exhibited antihepatotoxic activity in assays employing CCl4-, GalN-, and phalloidin-cytotoxicity in rat hepatocytes. They also showed a significant stimulatory effect on liver cell regeneration. A HPLC-method is described for qualitative and quantitative analysis of the coumestans, in the extracts of Eclipta alba and also Wedelia calendulacea Less., Asteraceae.