Concepedia

Carbonic-adsorbent AST-120 reduces overload of indoxyl sulfate and the plasma level of TGF-β1 in patients with chronic renal failure

Shuji Iida, Keisuke Kohno, Junko Yoshimura, Seiji Ueda, Michiaki Usui, Hiroshi Miyazaki, Hidemi Nishida, Kiyoshi Tamaki, Seiya Okuda

Clinical and Experimental Nephrology · 2006 · 40 citations · 21 references

DOI

Concepts

References

21

Elevated expression of transforming growth factor-beta and proteoglycan production in experimental glomerulonephritis. Possible role in expansion of the mesangial extracellular matrix.

Seiya Okuda, Lucia R. Languino, Erkki Ruoslahti et al. · Journal of Clinical Investigation · 1990 · 549 citations · Full text

, , +16

Transgenic mice with increased plasma levels of TGF-beta 1 develop progressive renal disease.

Jeffrey B. Kopp, V.M. Factor, M Mozes et al. · PubMed · 1996 · 424 citations

, , +10

Indoxyl sulfate, a circulating uremic toxin, stimulates the progression of glomerular sclerosis.

Takashi Niwa, Michihito Ise · PubMed · 1994 · 410 citations

, , +13

Increased Renal Production of Transforming Growth Factor-β1 in Patients with Type II Diabetes

Kumar Sharma, Fuad N. Ziyadeh, Bashar Alzahabi et al. · Diabetes · 1997 · 274 citations

, , +14

The protein metabolite hypothesis, a model for the progression of renal failure: an oral adsorbent lowers indoxyl sulfate levels in undialyzed uremic patients.

Tae Niwa, T Nomura, Shigeru Sugiyama et al. · PubMed · 1997 · 199 citations

, , +17