Rare, Nonsynonymous Variant in the Smooth Muscle-Specific Isoform of Myosin Heavy Chain, <i>MYH11</i> , R247C, Alters Force Generation in the Aorta and Phenotype of Smooth Muscle Cells

Abstract

These results indicate that a rare variant in MYH11, R247C, alters myosin contractile function and SMC phenotype, leading to increased proliferation in vitro and in response to vascular injury.