Quinazolinones, 13.Comm. Synthesis of 3‐[2‐(2,3‐Dihydro‐5‐phenyl‐4‐substituted‐3H‐1,2,4‐triazole‐3‐thione‐2‐yl)‐acetylamino]‐2‐methyl‐4(3H)‐quinazolinones and their pharmacological activities

Abstract

Some 2-methyl-3-triazole-substituted-4(3H)-quinazolinones 3a-f were prepared and tested for their H1- and H2-antihistaminic activities. In addition these compounds are central nervous system depressants and anticonvulsants. 3e shows highly significant decrease of locomotor activity.