Direct Allylation of Aldimines Catalyzed by <i>C</i>₂‐Symmetric <i>N</i>,<i>N′</i>‐Dioxide–Sc^III Complexes: Highly Enantioselective Synthesis of Homoallylic Amines

Abstract

The first catalytic asymmetric three-component allylation of aldimines has been developed. In the presence of L-ramipril acid-oriented N,N′-dioxide–ScIII complex catalyst, a range of homoallylic amines were formed in excellent enantioselectivities (up to 97 % ee) with good yields from corresponding aldehydes, 2-aminophenol and allyltributyltin (see scheme).