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ON THE NATURE OF THE INTERDEPENDENCE OF THE ADRENAL CORTEX, NON-SPECIFIC STRESS AND NUTRITION IN THE REGULATION OF NITROGEN METABOLISM*
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1952
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Adrenal CortexThe InterdependenceGlucocorticoidOxidative StressIntegrative PhysiologyMetabolic SyndromeAdrenal GlandNeuroendocrine MechanismNeurologyHealth SciencesAnimal PhysiologyEnergy HomeostasisStress HormoneAdrenal Cortex ParticipateAdrenal DiseaseNervous SystemEndocrinologyPhysiologySimple Causal RelationshipNeuroscienceMetabolismMedicineThe Adrenal Cortex
IT IS now widely recognized that the adrenal cortex is concerned in some fundamental way with the ability of the organism to respond to injury in a characteristic fashion. However, the precise mechanism by which the steroids of the adrenal cortex participate in the metabolic response to injury still remains speculative. Earlier studies in this area led to the concept which is still widely held that certain of the metabolic alterations after injury in the healthy organism are a direct consequence of hypersecretion of adrenal cortical steroids (Selye 1946). However, later work (see Engel, 1951a and b for a review of the literature) has cast doubt on such a simple causal relationship and relatively few investigators active in this field accept this concept any longer. The best evidence against it is found in the report of Ingle, Ward and Kuizenga (1947) who showed that the characteristic negative nitrogen balance which follows fractures in normal,