Bi(OTf)3-catalyzed Regioselective Ring Opening of Epoxides with Phenols: Facile Synthesis of 1,3-Diaryloxy-2-propanols

Abstract

Abstract Substituted aryl oxiranes undergo the facile ring opening with phenols in the presence of catalytic amount of bismuth(III) triflate to afford 1,3-diaryloxy-2-propanols in excellent yields under mild conditions. Bismuth(III) triflate is relatively non-toxic, easy to handle and inexpensive, which makes this procedure particularly attractive for large scale synthesis.