A novel Germline mutation in <i>HOXB13</i> is associated with prostate cancer risk in Chinese men

Abstract

We identified a novel rare mutation in the HOXB13 gene, G135E, which appears to be a founder mutation. This mutation is associated with increased PCa risk in Chinese men. Consistent with a previous report, our findings provide further evidence that rare mutations in HOXB13 contribute to PCa risk.