Electrochemical DNA Biosensors Based on DNA-Drug Interactions

Abstract

The world of drug designing is ever changing. The investigations of drug-DNA interactions would provide new compounds to be tested for an effect on a biochemical target, and also to be used as promising hybridization indicators for the design of DNA biosensors, which will further become DNA microchip systems. An overview is reported here about DNA biosensors based primarily on drugs interacting with DNA and shows how to determine this interaction electrochemically, the quantification of drug and/or DNA, and the promising applications of these drugs as DNA hybridization indicator. The applications of these electrochemical DNA biosensors are described and discussed.