Development of a Model of Elevated Intraocular Pressure in Rats by Gene Transfer of Bone Morphogenetic Protein 2

Abstract

Gene transfer of the calcification inducer BMP2 gene to the trabecular meshwork induces elevated IOP in living rats without altering the basic structure of the tissue. This strategy generates an elevated IOP model in rats that would be useful for evaluation of glaucoma drugs targeting the outflow pathway.