A Randomized Clinical Trial of High-Dose Epinephrine and Norepinephrine vs Standard-Dose Epinephrine in Prehospital Cardiac Arrest

Abstract

High-dose epinephrine significantly improves the rate of return of spontaneous circulation and hospital admission in patients who are in prehospital cardiac arrest without increasing complications. However, the increase in hospital discharge rate is not statistically significant, and no significant trend could be determined for neurological outcome. No benefit of NE compared with HDE was identified. Further study is needed to determine the optimal role of epinephrine in prehospital cardiac arrest.