Effector CD8⁺T cell IFN-<i>γ</i>production and cytotoxicity are enhanced by mild hyperthermia

Abstract

Antigen-dependent effector T cell activity is enhanced following mild hyperthermia. These effects could potentially occur in patients being treated with thermal therapies. These data also provide support for the use of thermal therapy as an adjuvant for immunotherapies to improve CD8+ effector cell function.