Up-Regulation of Platelet-Activating Factor Synthases and its Receptor in Spinal Cord Contribute to Development of Neuropathic Pain following Peripheral Nerve Injury

Abstract

Our data show the histological localization of PAF synthases and its receptor in the spinal cord following peripheral nerve injury, and suggest that PAF/PAFr signaling in the spinal cord acts in an autocrine or paracrine manner among the activated microglia and neurons, thus contributing to development of neuropathic pain.