1c:I[419806,["/_next/static/chunks/bb923814e1f4d2e9.js","/_next/static/chunks/dd3ee9f5b7716ca6.js","/_next/static/chunks/4204a0ae82542ca8.js","/_next/static/chunks/1270dead247da766.js","/_next/static/chunks/6e1aa89a642f40be.js","/_next/static/chunks/2d7aa753e81324a8.js","/_next/static/chunks/8ffd0b71567920d8.js","/_next/static/chunks/67ea6dfd21f16c5f.js","/_next/static/chunks/24eb4379f68013fd.js","/_next/static/chunks/b8cd775ffdf935bd.js","/_next/static/chunks/983103cd9eb7b428.js","/_next/static/chunks/263f2cdcb9aa2341.js","/_next/static/chunks/294b9525248c8e5f.js"],"default"] 1d:T4bf,Skin photoaging is primarily caused by ultraviolet radiation and can lead to the degradation of skin extracellular matrix components, resulting in hyperpigmentation and skin elasticity loss. In this area, polyphenols have become of great interest because of their antioxidant, anti-inflammatory and antiaging properties. Here, we evaluated the effects of the pomegranate natural extract Pomanox^® on skin health-related parameters in normal and UV-induced photoaging conditions in human fibroblast Hs68 cells. Moreover, the inhibitory effects of Pomanox^® on tyrosinase activity were assessed. In normal conditions, Pomanox^® significantly modulated collagen and hyaluronic acid metabolisms. In UV-exposed cells, both preventive and regenerative treatments with Pomanox^® positively modulated hyaluronic acid metabolism and decreased ROS levels. However, only the preventive treatment modulated collagen metabolism. Finally, Pomanox^® showed a marked inhibitory capacity of tyrosinase activity (IC50 = 394.7 μg/mL). The modulation of skin health-related parameters exhibited by Pomanox^® open a wide range of potential applications of this product.1e:T447,This article examines the relationship between immigration policy and crime in seven nations. The countries involved are Australia, Canada, France, Germany, Great Britain, Japan, and the United States. Immigration policy and the criminal involvement of immigrants are compared to determine whether there is a pattern between the two, what that pattern is, and why it exists. The nations examined have very different immigration policies. Some are "immigrant nations," where the volume of immigrants is high, barriers to entry are low, and naturalization is encouraged. Others are "nonimmigrant nations," in which the volume of immigration is relatively low, the barriers to entry are substantial, and permanent settlement and attainment of citizenship are not encouraged. There is a general (but not perfect) pattern in which "immigrant" nations have lower ratios of immigrant to native crime than nations with less liberal policies. It is not clear whether this relationship is due more to the general ability of these nations to integrate foreign populations or to immigration policies per se.

	Year	Citations

References