Science · 1996 · 244 citations · 15 references
Life SciencesBiochemistryMolecular BiologyDna RepairEnzymologyNucleic Acid BiochemistryPhotoreceptor Gene FunctionPhotoreceptor PhysiologyCyclobutane Pyrimidine DimersDna Damage InductionLight-dependent Dna RepairPyrimidine (6-4) Pyrimidone PhotoproductsPyrimidine(6-4)pyrimidone PhotoproductsRepair Of Uv-induced Dna DamageUltraviolet-induced Dna DamageUv-induced Dna Lesions
Ultraviolet light (UV)-induced DNA damage can be repaired by DNA photolyase in a light-dependent manner. Two types of photolyase are known, one specific for cyclobutane pyrimidine dimers (CPD photolyase) and another specific for pyrimidine (6-4) pyrimidone photoproducts[(6-4)photolyase]. In contrast to the CPD photolyase, which has been detected in a wide variety of organisms, the (6-4)photolyase has been found only in Drosophila melanogaster. In the present study a gene encoding the Drosophila(6-4)photolyase ws cloned, and the deduced amino acid sequence of the product was found to be similar to the CPD photolyase and to the blue-light photoreceptor of plants. A homolog of the Drosophila (6-4)photolyase gene was also cloned from human cells.
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Crystal Structure of DNA Photolyase from <i>Escherichia coli</i>
Hee-Won Park, Sang‐Tae Kim, Aziz Sancar et al. · Science · 1995 · 577 citations