Cardiovascular and Renal Effects of Enflurane in Surgical Patients

Abstract

In 21 surgical patients studied at varying end-expired concentrations (mean 1.1 percent) and in 12 surgical patients studied specifically at 1 MAC (approximately 1 percent) in 60 percent nitrous oxide (N2O), stroke volume, cardiac output, and arterial pressures were found to decrease significantly with enflurane anesthesia, but heart rate and systemic resistance changed little. In renal screening studies (BUN, creatinine, and uric-acid determinations, urinalysis, and measurement of urinary output volume) in 50 patients preoperatively and postoperatively and in urinalyses in 150 others, the only significant change was persistence of cloudy urine and albuminuria up to 10 days, with no clinically significant derangement in the other tests.