The phytoestrogens Genistein and Daidzein, and 17β-estradiol inhibit development of neointima in aortas from male and female rabbits in vitro after injury

Abstract

Genistein and Daidzein both inhibited proliferation at certain concentrations, so this effect is supposed to be independent from Genistein's protein tyrosine kinase activity. The antiproliferative properties of all three estrogens were observed in the absence of endothelium and therefore are independent from endothelium-mediated effects.