Killing of Escherichia coli by Crohnʼs Disease Monocyte-derived Macrophages and Its Enhancement by Hydroxychloroquine and Vitamin D

Abstract

CD and HC macrophages perform similarly in allowing replication of phagocytosed E. coli and generating neutrophil chemoattractants. Replication of phagocytosed E. coli was substantially decreased by HCQ and vitamin D. These warrant further therapeutic trials in CD in combination with relevant antibiotics.