Topochemical Click Reaction: Spontaneous Self‐Stitching of a Monosaccharide to Linear Oligomers through Lattice‐Controlled Azide–Alkyne Cycloaddition

Abstract

No activation needed: A topochemical click reaction that dispenses with catalyst, solvent, or other modes of activation takes place in crystals of a sugar derivative. The spontaneous, regiospecific azide–alkyne cycloaddition gives linear polymers that are difficult to synthesize by conventional solution-state chemistry (see picture).