Sodium???hydrogen antiporter protein in normotensive Wistar???Kyoto rats and spontaneously hypertensive rats

Abstract

The increased Na-H antiport activity observed in SHR cells in vitro and in vivo is not due to an increased amount of NHE-1 protein in SHR cells. This suggests that in this model of hypertension the increased transport activity results from an increased turnover number per NHE-1 molecule.