Nitric Oxide Synthase-Dependent Vasodilation of Human Subcutaneous Arterioles Correlates With Noninvasive Measurements of Endothelial Function

Abstract

Acetylcholine vasodilator responses in human gluteal subcutaneous arterioles are NO synthase dependent and correlate with cardiac risk factors and in vivo measures of endothelial function. These data suggest subcutaneous arterioles offer an opportunity for translational studies of mechanisms of modulating NO bioavailability relevant to in vivo endothelial function measures.