Concepedia

Facile, solvent and ligand free iron catalyzed direct functionalization of N-protected tetrahydroisoquinolines and isochroman

Michael Ghobrial, Karin Harhammer, Marko D. Mihovilovič, Michael Schnürch

Chemical Communications · 2010 · 182 citations · 28 references

DOI

Concepts

Abstract

An efficient method for an iron catalyzed oxidative indolation and methoxyphenylation of N-protected tetrahydroisoquinolines and isochroman is described including subsequent facile deprotection.

References

28

Cross-Dehydrogenative Coupling (CDC): Exploring C−C Bond Formations beyond Functional Group Transformations

Chao‐Jun Li · Accounts of Chemical Research · 2008 · 2.8K citations

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CuBr-Catalyzed Efficient Alkynylation of sp<sup>3</sup> C−H Bonds Adjacent to a Nitrogen Atom

Zhiping Li, Chao‐Jun Li · Journal of the American Chemical Society · 2004 · 665 citations

, , +12

Highly Efficient Copper-Catalyzed Nitro-Mannich Type Reaction:  Cross-Dehydrogenative-Coupling between sp<sup>3</sup> C−H Bond and sp<sup>3</sup> C−H Bond

Zhiping Li, Chao‐Jun Li · Journal of the American Chemical Society · 2005 · 538 citations

, , +11

CuBr-Catalyzed Direct Indolation of Tetrahydroisoquinolines via Cross-Dehydrogenative Coupling between sp<sup>3</sup> C−H and sp<sup>2</sup> C−H Bonds

Zhiping Li, Chao‐Jun Li · Journal of the American Chemical Society · 2005 · 505 citations

, , +15

Copper-Catalyzed Coupling of Alkylamines and Aryl Iodides:  An Efficient System Even in an Air Atmosphere

Fuk Yee Kwong, Artis Klapars, Stephen L. Buchwald · Organic Letters · 2002 · 504 citations

, , +11