Hematopoietic Microchimerism in Sheep After In Utero Transplantation of Cultured Cynomolgus Embryonic Stem Cells

Abstract

Long-term hematopoietic microchimerism from primate ES cells was observed after in vitro differentiation to mesodermal cells, followed by in vivo introduction into the fetal liver microenvironment. The mechanism of such directed differentiation of ES cells remains to be elucidated, but this procedure should allow further investigation.