TNFα is a key mediator of the pronociceptive effects of mucosal supernatant from human ulcerative colitis on colonic DRG neurons

Abstract

UC supernatants enhance neuronal excitability of sensory dorsal root ganglia neurons innervating the colon. TNFalpha is a key mediator which acts at neuronal TNFR1 to modulate K(v) and Na(v) currents. Together these data provide a number of potential new targets for pain management in UC.