Upregulation of Arginase by H₂O₂Impairs Endothelium-Dependent Nitric Oxide-Mediated Dilation of Coronary Arterioles

Abstract

H2O2 specifically impairs endothelium-dependent NO-mediated dilation of coronary microvessels by reducing L-arginine availability through upregulation of arginase. The formation of hydroxyl radicals from H2O2 may contribute to this process.